Chemistry for Imaging in-situ Protein Palmitoylation

Click on Chemistry for Imaging in-situ Protein Palmitoylation throughout the Asexual Levels of Plasmodium falciparum

Palmitoylation refers back to the modification of the cysteine thiols in proteins by fatty acids, mostly palmitic acid, via ‘thioester bond’ formation. In vivo, palmitoylation of proteins is catalyzed by palmitoyl acyltransferases (PATs or DHHC-PATs). Palmitoylation has just lately emerged as a vital post-translational modification in malarial parasites. The expression and exercise of palmitoyl transferases differ throughout totally different developmental phases of the malarial parasite’s life cycle. The abundance of palmitoylated proteins at a given stage is a measure of total PAT exercise. The PAT exercise may also change in response to exterior alerts or inhibitors.

Right here, we describe a protocol to ‘picture’ palmitoyl-transferase exercise throughout the asexual phases utilizing Click on Chemistry and fluorescence microscopy. This methodology is predicated on metabolic labeling of a clickable analog of palmitic acid by parasitic cells, adopted by CuAAC (Copper-catalyzed Alkyne-Azide Cycloaddition response) Click on Chemistry to render palmitoylated proteins fluorescent. Fluorescence permits the quantitation of intracellular palmitoylation in parasite cells throughout numerous improvement phases. Utilizing this methodology, we noticed that intracellular palmitoylation will increase because the parasite transitions from ring to schizont phases and seems to be most plentiful throughout the schizont phases in Plasmodium falciparum.

mmune subtraction for improved decision in serum protein immunofixation electrophoresis and antibody isotype willpower in a affected person with autoantibody

Heavy chain isotypes of low degree monoclonal immunoglobulins are typically obscured in serum immunofixation electrophoresis (SIFE) by a heavy background of polyclonal immunoglobulins. Nevertheless, correct willpower of the heavy chain isotype is crucial for an entire analysis, as isotype willpower of autoantibodies could have relevance in figuring out therapeutic procedures. Immune subtraction (IS) was employed in a affected person with neuropathy and GD1a autoantibody. IS allowed identification of the cognate heavy chain associated to a lambda gentle chain restriction famous on preliminary SIFE in addition to isotype willpower of the autoantibody.

Antisera particular to particular person heavy and lightweight chains had been used for depletion of particular immunoglobulin varieties. Depletion of kappa gentle chain related immunoglobulins allowed unequivocal willpower of the isotype of lambda gentle chain-associated low degree monoclonal band to be IgG Lambda. Selective depletion of kappa, lambda, gamma and mu heavy chain immunoglobulins was employed to find out IgG Kappa isotype of the auto-antibody.

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Panspecific Nuclear Pore Complex Marker
MO22107 500 ul
EUR 344
Nuclear pore complex protein Nup153 Antibody (HRP)
20-abx108567
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Nuclear pore complex protein Nup153 Antibody (Biotin)
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Nuclear pore complex protein Nup98 (315-360)
HY-P1730 1mg
EUR 1140
Human Nuclear pore complex protein Nup153 (NUP153)
1-CSB-EP016190HU
  • EUR 380.00
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  • MW: 27.3 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Nuclear pore complex protein Nup153(NUP153),partial expressed in E.coli
Recombinant human Nuclear pore complex protein Nup133
P2220 100ug Ask for price
  • Uniprot ID: Q8WUM0
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Nuclear pore complex protein Nup133
Nuclear pore membrane glycoprotein 210 Antibody (FITC)
20-abx107147
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Nuclear Pore Complex-Interacting Protein-Like 2 (NPIPL2) Antibody
abx034938-400ul 400 ul
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Nuclear Pore Complex-Interacting Protein-Like 2 (NPIPL2) Antibody
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Nuclear pore membrane glycoprotein 210 Polyclonal Conjugated Antibody
C42276 100ul
EUR 397
Mouse Nuclear pore complex protein Nup54, Nup54 ELISA KIT
ELI-21319m 96 Tests
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Mouse Nuclear pore complex protein Nup160, Nup160 ELISA KIT
ELI-21357m 96 Tests
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Mouse Nuclear pore complex protein Nup214, Nup214 ELISA KIT
ELI-21358m 96 Tests
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Human Nuclear pore complex protein Nup50, NUP50 ELISA KIT
ELI-22432h 96 Tests
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ELI-23491b 96 Tests
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Human Nuclear pore complex protein Nup155, NUP155 ELISA KIT
ELI-15040h 96 Tests
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ELI-16689h 96 Tests
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ELI-35536m 96 Tests
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ELI-44222h 96 Tests
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Bovine Nuclear pore complex protein Nup93, NUP93 ELISA KIT
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Mouse Nuclear pore complex protein Nup133, Nup133 ELISA KIT
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ELI-44561m 96 Tests
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Human Nuclear pore complex protein Nup153, NUP153 ELISA KIT
ELI-44867h 96 Tests
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ELI-46087h 96 Tests
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Mouse Nuclear pore complex protein Nup107, Nup107 ELISA KIT
ELI-38239m 96 Tests
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Human Nuclear pore complex protein Nup160, NUP160 ELISA KIT
ELI-38240h 96 Tests
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ELI-38242h 96 Tests
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SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody
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SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody
20-abx126518
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SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody
abx025879-400ul 400 ul
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SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody
abx025879-80l 80 µl
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ELI-13775h 96 Tests
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ELISA kit for Rat Nuclear pore complex protein Nup153 (NUP153)
KTE100879-48T 48T
EUR 332
  • Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to th
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Description: Quantitative sandwich ELISA for measuring Rat Nuclear pore complex protein Nup153 (NUP153) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Rat Nuclear pore complex protein Nup153 (NUP153)
KTE100879-5platesof96wells 5 plates of 96 wells
EUR 2115
  • Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to th
  • Show more
Description: Quantitative sandwich ELISA for measuring Rat Nuclear pore complex protein Nup153 (NUP153) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Rat Nuclear pore complex protein Nup153 (NUP153)
KTE100879-96T 96T
EUR 539
  • Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to th
  • Show more
Description: Quantitative sandwich ELISA for measuring Rat Nuclear pore complex protein Nup153 (NUP153) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Nuclear pore membrane glycoprotein 210 Antibody
20-abx110055
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Goat Anti-Green Fluorescent Proteins (GFP, A. victoria) protein IgG-FITC conjugate
GFP11-FITC 100 ug
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GFP12-FITC 0.5 ml
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QP6439-ec-100ug 100ug
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Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-10ug
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Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-1mg
QP6439-ec-1mg 1mg
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Nuclear pore membrane glycoprotein 210 Antibody (HRP)
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Nuclear pore membrane glycoprotein 210 Antibody (Biotin)
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42276-100ul 100ul
EUR 333
Anti-Human CD44 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-Human CD28 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD14 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD11b Monoclonal Antibody FITC Conjugated, Flow Validated
FC00144-FITC 25 Tests, 100 Tests, 200 Tests
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Anti-human CD19 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00154-FITC 25 Tests, 100 Tests, 200 Tests
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Anti-human CD38 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00193-FITC 25 Tests, 100 Tests, 200 Tests
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Anti-human CD25 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD4 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00344-FITC 25 Tests, 100 Tests, 200 Tests
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Anti-human CD5 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD45 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD2 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD71 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00591-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
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Anti-human CD62L Monoclonal Antibody FITC Conjugated, Flow Validated
FC00652-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
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Anti-human CD59 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00914-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
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Anti-Human CD81 Monoclonal Antibody FITC Conjugated, Flow Validated
FC01281-FITC 25 Tests, 100 Tests, 200 Tests
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Anti-human CD117 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD16 Monoclonal Antibody FITC Conjugated, Flow Validated
FC01408-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
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Anti-human CD32 Monoclonal Antibody FITC Conjugated, Flow Validated
FC01450-FITC 25 Tests, 100 Tests, 200 Tests
EUR 120
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Anti-Human CD31 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD90 Monoclonal Antibody FITC Conjugated, Flow Validated
FC01818-FITC 25 Tests, 100 Tests, 200 Tests
EUR 153
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Anti-human CD7 Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD235a Monoclonal Antibody FITC Conjugated, Flow Validated
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Anti-human CD8 Monoclonal Antibody FITC Conjugated, Flow Validated
FC02236-FITC 25 Tests, 100 Tests, 200 Tests
EUR 96
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Anti-human CD13 Monoclonal Antibody FITC Conjugated, Flow Validated
FC02591-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
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Anti-human CD3 Monoclonal Antibody FITC Conjugated, Flow Validated
FC02675-FITC 25 Tests, 100 Tests, 200 Tests
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Anti-human CD20 Monoclonal Antibody FITC Conjugated, Flow Validated
FC03780-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
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Anti-Human CD161 Monoclonal Antibody FITC Conjugated, Flow Validated
FC03917-FITC 25 tests, 100 tests
EUR 160
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Anti-human CD10 Monoclonal Antibody FITC Conjugated, Flow Validated
FC04065-FITC 25 Tests, 100 Tests, 200 Tests
EUR 125
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Anti-Human CD3 Monoclonal Antibody FITC Conjugated, Flow Validated
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EUR 96
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Anti-Human CD11a Monoclonal Antibody FITC Conjugated, Flow Validated
FC04466-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
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Anti-human CD15 Monoclonal Antibody FITC Conjugated, Flow Validated
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EUR 137
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Anti-Human CD66b Monoclonal Antibody FITC Conjugated, Flow Validated
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EUR 137
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Anti-human CD57 Monoclonal Antibody FITC Conjugated, Flow Validated
FC09548-FITC 25 Tests, 100 Tests, 200 Tests
EUR 140
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Rabbit Anti-purified protein derivative (PPD and most proteins of M. tuberculosis) IgG-FITC conjugate
PPD11-FITC 100 ul
EUR 445
Recombinant rat Nuclear pore glycoprotein p62
P1858 100ug Ask for price
  • Uniprot ID: P17955
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for rat Nuclear pore glycoprotein p62
Anti-human HLA-DR Monoclonal Antibody FITC Conjugated, Flow Validated
FC00568-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human HLA-DR Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Anti-human CD55/Daf Monoclonal Antibody FITC Conjugated, Flow Validated
FC00910-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD55/Daf Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Anti-Mouse TCR beta Monoclonal Antibody FITC Conjugated, Flow Validated
FC09166-FITC 25 ug, 100ug, 500ug
EUR 91
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Anti-Human HLA-ABC Monoclonal Antibody FITC Conjugated, Flow Validated
FC20056-FITC 25 Tests , 100 Tests , 200 Tests
EUR 137
Description: Mouse Monoclonal Human HLA-ABC Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Nuclear Pore Membrane Glycoprotein 210-Like (NUP210L) Antibody
20-abx121185
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
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Nuclear Pore Membrane Glycoprotein 210-Like (NUP210L) Antibody
20-abx217285
  • EUR 425.00
  • EUR 342.00
  • 100 ug
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Human SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) ELISA Kit
abx383083-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
Anti-Human CD54 (ICAM-1) Monoclonal Antibody FITC Conjugated, Flow Validated
FC00171-FITC 25 tests, 100 tests
EUR 149
Description: Mouse Monoclonal Human CD54 (ICAM-1) Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Anti-human CD33/Siglec 3 Monoclonal Antibody FITC Conjugated, Flow Validated
FC01508-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD33/Siglec 3 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Anti-human CD22/Siglec 2 Monoclonal Antibody FITC Conjugated, Flow Validated
FC01572-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD22/Siglec 2 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Human Nuclear pore membrane glycoprotein 210 (NUP210)
1-CSB-EP016195HU(C)
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 34.5 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Nuclear pore membrane glycoprotein 210(NUP210),partial expressed in E.coli
Human Nuclear pore membrane glycoprotein 210 (NUP210)
1-CSB-EP016195HU(N)
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 27.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Nuclear pore membrane glycoprotein 210(NUP210),partial expressed in E.coli
Rabbit anti-Nuclear pore glycoprotein p62 antiserum
NUP6211-S 100 ul
EUR 457
Anti-Human CD14 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00137-FITC-1 25 Tests, 100 Tests, 200 Tests
EUR 95
Description: Mouse Monoclonal Human CD14 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Anti-Mouse CD19 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00154-1-FITC 25ug, 100ug, 500ug
EUR 96
Description: Rat Monoclonal Mouse CD19 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Mouse.
Anti-Human CD54 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00171-FITC-1 25 Tests, 100 Tests, 200 Tests
EUR 130
Description: Mouse Monoclonal Human CD54 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Anti-Mouse CD4 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00344-3-FITC 25ug, 100ug, 500ug
EUR 85
Description: Rat Monoclonal Mouse CD4 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Mouse.
Anti-Mouse CD45.2 Monoclonal Antibody FITC Conjugated, Flow Validated
FC00555-8-FITC 25ug, 100ug, 500ug
EUR 96
Description: Mouse Monoclonal Mouse CD45.2 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Mouse.
Anti-Human CD45RO Monoclonal Antibody FITC Conjugated, Flow Validated
FC00555-FITC-1 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal Human CD45RO Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Anti-Human CD3 Monoclonal Antibody FITC Conjugated, Flow Validated
FC02675-FITC-1 25 Tests, 100 Tests, 200 Tests
EUR 73
Description: Mouse Monoclonal Human CD3 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Anti-Mouse CD3e Monoclonal Antibody FITC Conjugated, Flow Validated
FC04405-3-FITC 25ug, 100ug, 500ug
EUR 79
Description: Hamster Monoclonal Mouse CD3e Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Mouse.
Anti-Human CD3 Monoclonal Antibody FITC Conjugated, Flow Validated
FC04405-4-FITC 25 tests, 100 tests, 500 tests
EUR 96
Description: Mouse Monoclonal Human CD3 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Nuclear Pore-Associated Protein 60 kDa-Like (Npap60) Antibody
abx430652-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.
F(ab')2 fragment,Goat Anti-Mouse IgG (Fc) IgG-FITC Conjugate (adsorbed with bovine, horse, and human serum proteins)
40152-FITC 0.5 ml
EUR 250
Monoclonal antibody for HSP90 complex
SMC-109B-FITC 0.2mg
EUR 524
  • HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral componen
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Description: A monoclonal antibody from clone 8D3 against Human | Mouse | Shark | Gummy Shark (Mustelus antarcticus) | School Shark (Galeorhinus galeus) | Dog HSP90 complex. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Ah receptor (Aryl hydrocarbon receptor). The antibody is tested and validated for IP, ICC/IF assays with the following recommended dilutions: ICC/IF (1:100), IP (1:1000). This MAb for HSP90 complex is conjugated with FITC.
Mouse anti-human CD7 Monoclonal Antibody FITC Conjugated, Flow Validated
FC01974-1-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal Mouse human CD7 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Human Nuclear pore glycoprotein p62, NUP62 ELISA KIT
ELI-22574h 96 Tests
EUR 824
Mouse Nuclear pore glycoprotein p62, Nup62 ELISA KIT
ELI-38235m 96 Tests
EUR 865
Lys proteins Antibody
abx219526-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.
Lys proteins Antibody
ABD2705 100 ug
EUR 438
Lys proteins Antibody
DF2705 200ul
EUR 304
Description: Lys proteins antibody detects endogenous levels of total Lys proteins.
Human Nuclear pore membrane glycoprotein 210, NUP210 ELISA KIT
ELI-19703h 96 Tests
EUR 824
Control/Blocking Peptide Nuclear pore membrane glycoprotein Nup210 (GP210)
GP210-11C 100 ug
EUR 225
Rabbit anti-Nuclear pore membrane glycoprotein Nup210 (GP210) antiserum
GP210-11S 100 ul
EUR 457
Mouse Nuclear pore membrane glycoprotein 210, Nup210 ELISA KIT
ELI-45547m 96 Tests
EUR 865
Cytomegalovirus Early Nuclear Antigen (CMV-EA Nuclear) Antibody (FITC)
abx411281-01mg 0.1 mg
EUR 509
  • Shipped within 1 week.
Pyruvate Dehydrogenase Complex (PDH Complex) AssayLite Antibody (FITC Conjugate)
30022-05141 150 ug
EUR 428
Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) Antibody (FITC)
20-abx303402
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Heterogeneous nuclear ribonucleoprotein Q Antibody (FITC)
20-abx106930
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Nuclear receptor ROR gamma Antibody (FITC)
20-abx107148
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Small nuclear ribonucleoprotein G Antibody (FITC)
20-abx107338
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
SOSS complex subunit B2 Antibody (FITC)
20-abx107345
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
T-Complex 10 (TCP10) Antibody (FITC)
20-abx306812
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
THO Complex 7 (THOC7) Antibody (FITC)
20-abx307861
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
GNAS Complex Locus (GNAS) Antibody (FITC)
20-abx337232
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
T-Complex 1 (TCP1) Antibody (FITC)
20-abx337920
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
THO Complex 5 (THOC5) Antibody (FITC)
20-abx337956
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Thrombin/Antithrombin Complex (TAT) Antibody (FITC)
20-abx338138
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Major urinary proteins 11 and 8 Polyclonal Conjugated Antibody
C42636 100ul
EUR 397
Nuclear Matrix Protein p84 Conjugated Antibody
C49738 100ul
EUR 397
Small Nuclear RNA Activating Complex Polypeptide 5 (SNAPC5) Antibody
20-abx325174
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.
Small Nuclear RNA Activating Complex Polypeptide 5 (SNAPC5) Antibody
20-abx218687
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.
Small Nuclear RNA Activating Complex Polypeptide 5 (SNAPC5) Antibody
abx238059-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.
CD7 antibody - FITC conjugated
61R-2068 1000 tests
EUR 435
Description: Monoclonal CD7 FITC Conjugated Antibody
GLIPR2 Antibody, FITC conjugated
1-CSB-PA880974LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against GLIPR2. Recognizes GLIPR2 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
EBF3 Antibody, FITC conjugated
1-CSB-PA880977LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against EBF3. Recognizes EBF3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
C11orf1 Antibody, FITC conjugated
1-CSB-PA880979LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against C11orf1. Recognizes C11orf1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
RABEP2 Antibody, FITC conjugated
1-CSB-PA880980LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against RABEP2. Recognizes RABEP2 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
CXorf56 Antibody, FITC conjugated
1-CSB-PA880981LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against CXorf56. Recognizes CXorf56 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
FAM124B Antibody, FITC conjugated
1-CSB-PA880982LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against FAM124B. Recognizes FAM124B from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
ELAC1 Antibody, FITC conjugated
1-CSB-PA880988LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against ELAC1. Recognizes ELAC1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
DCLRE1B Antibody, FITC conjugated
1-CSB-PA880993LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against DCLRE1B. Recognizes DCLRE1B from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
WDR54 Antibody, FITC conjugated
1-CSB-PA881001LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against WDR54. Recognizes WDR54 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
LRRC40 Antibody, FITC conjugated
1-CSB-PA881002LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against LRRC40. Recognizes LRRC40 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
NHEJ1 Antibody, FITC conjugated
1-CSB-PA881005LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against NHEJ1. Recognizes NHEJ1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
SLC52A2 Antibody, FITC conjugated
1-CSB-PA881008LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against SLC52A2. Recognizes SLC52A2 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Antifreeze Protein Supplementation In the course of the Warming of Vitrified Bovine Ovarian Tissue Can Enhance the Ovarian Tissue High quality After Xenotransplantation

 

The prevalence of ice crystallization throughout ovarian tissue (OT) cryopreservation causes unavoidable cryodamage, and ice recrystallization throughout the warming is extra detrimental than ice crystallization. Right here, we investigated that antifreeze protein (AFP) therapy throughout the warming process can enhance the bovine OT high quality after xenotransplantation (XT). Bovine OTs (n=120) had been evenly assigned to 4 teams: contemporary, vitrified-warmed, vitrified-warmed with 10 mg/mL Leucosporidium ice-binding protein (LeIBP, a sort of AFP) (LeIBP-10), and vitrified-warmed with 20 mg/mL LeIBP (LeiBP-20). LeIBPs had been added to the primary warming answer. Twenty items of OTs had been assigned to every class. The remaining 10 OTs from every class had been assigned to the XT-Recent management, XT-Vitrified-warmed management, XT-LeIBP-10, and XT-LeIBP-20 teams, respectively, and xenotransplanted to 9-week-old ovariectomized nude mice for one week.

LeIBP therapy throughout the warming step elevated morphological follicle normality and decreased apoptotic follicle ratios after vitrification-warming and XT. The XT-vitrified-warmed management group confirmed considerably decreased microvessel density and elevated fibrosis when in comparison with that of the XT-fresh group. Microvessel density and fibrosis had been recovered in each LeIBP handled teams. There was no vital distinction between the LeIBP-10 and LeIBP-20 teams in all outcomes. AFP therapy throughout the warming process can stop OT injury, and enhance ovarian follicle morphology and apoptosis in each the vitrified-warmed bovine OT and its graft. After affirmation in a human examine, AFPs can doubtlessly be utilized to human OT cryopreservation to cut back cryodamage and enhance the OT high quality.

Attenuated Induction of the Unfolded Protein Response in Grownup Human Major Astrocytes in Response to Recurrent Low Glucose

Goals/speculation: Recurrent hypoglycaemia (RH) is a serious side-effect of intensive insulin remedy for folks with diabetes. Modifications in hypoglycaemia sensing by the mind contribute to the event of impaired counterregulatory responses to and consciousness of hypoglycaemia. Little is understood in regards to the intrinsic adjustments in human astrocytes in response to acute and recurrent low glucose (RLG) publicity.

Strategies: Human main astrocytes (HPA) had been uncovered to zero, one, three or 4 bouts of low glucose (0.1 mmol/l) for 3 hours per day for 4 days to imitate RH. On the fourth day, DNA and RNA had been collected. Differential gene expression and ontology analyses had been carried out utilizing DESeq2 and GOseq, respectively. DNA methylation was assessed utilizing the Infinium MethylationEPIC BeadChip platform.

Outcomes: 24 differentially expressed genes (DEGs) had been detected (after correction for a number of comparisons). One bout of low glucose publicity had the most important impact on gene expression. Pathway analyses revealed that endoplasmic-reticulum (ER) stress-related genes comparable to HSPA5XBP1, and MANF, concerned within the unfolded protein response (UPR), had been all considerably elevated following low glucose (LG) publicity, which was diminished following RLG. There was little correlation between differentially methylated positions and adjustments in gene expression but the variety of bouts of LG publicity produced distinct methylation signatures.

Conclusions/interpretation: These knowledge counsel that publicity of human astrocytes to transient LG triggers activation of genes concerned within the UPR linked to endoplasmic reticulum (ER) stress. Following RLG, the activation of UPR associated genes was diminished, suggesting attenuated ER stress. This can be a consequence of a profitable metabolic adaptation, as beforehand reported, that higher preserves intracellular vitality ranges and a decreased necessity for the UPR.

Doxorubicin/Nucleophosmin Binding Protein-Conjugated Nanoparticle Enhances Anti-leukemia Exercise in Acute Lymphoblastic Leukemia Cells in vitro and in vivo

Acute lymphoblastic leukemia (ALL) is an aggressive malignancy. Adults with ALL have greater than 50% relapse charges. We have now beforehand validated that overexpression of nucleophosmin (NPM) is concerned within the multidrug resistance (MDR) improvement throughout ALL; and a synthetically engineered recombinant NPM binding protein (NPMBP) has been developed in our group; NPMBP and doxorubicin (DOX) could be conjugated in a nanoparticle-based drug supply system named DOX-PMs-NPMBP to counteract MDR throughout ALL. Right here, we evaluated the antileukemia potential of DOX-PMs-NPMBP in resistant ALL cells. This examine demonstrates that DOX-PMs-NPMBP considerably enhances chemosensitivity to DOX in ALL cells.

Regardless of at variable concentrations, each resistant and first ALL cells from relapsed sufferers had been delicate to DOX-PMs-NPMBP. Intimately, the half maximal inhibitory focus (IC50) values of DOX-PMs-NPMBP had been between 1.6- and seven.0-fold decrease than these of DOX in cell strains and first ALL cells, respectively; and apoptotic cells ratio was over 2-fold increased in DOX-PMs-NPMBP than DOX. Mechanistically, p53-driven apoptosis induction and cell cycle arrest performed important position in DOX-PMs-NPMBP-induced anti-leukemia results. Furthermore, DOX-PMs-NPMBP considerably inhibited tumor progress and extended mouse survival of ALL xenograft fashions; and no systemic toxicity prevalence was noticed after therapy throughout follow-up. In conclusion, these knowledge point out that DOX-PMs-NPMBP could considerably exert progress inhibition and apoptosis induction, and markedly enhance DOX antileukemia exercise in resistant ALL cells. This novel drug supply system could also be invaluable to develop as a brand new therapeutic technique towards multidrug resistant ALL.

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